Neutrophils roll on adherent neutrophils bound to cytokine-induced endothelial cells via L-selectin on the rolling cells
| Autor: | Sandy Kurk, Mark A. Jutila, Eugene C. Butcher, R F Bargatze |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Endothelium
Neutrophils medicine.medical_treatment Immunology In vivo Cell Adhesion medicine Humans Immunology and Allergy L-Selectin Cell adhesion Cell Aggregation biology Cell adhesion molecule Chemistry Antibodies Monoclonal Articles Neutrophil extracellular traps Cell aggregation Cell biology medicine.anatomical_structure Cytokine biology.protein Cytokines L-selectin Endothelium Vascular Cell Adhesion Molecules |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.180.5.1785 |
| Popis: | Specific arrest of neutrophils in venules is central to their rapid accumulation during local inflammatory responses. Initial neutrophil rolling on endothelium is mediated by leukocyte L-selectin and the inducible vascular adhesion proteins P- and E-selectin. This rolling is a prerequisite for endothelial-dependent neutrophil arrest. Here we describe rolling of neutrophils on the surface of previously arrested neutrophils and demonstrate that this interaction involves L-selectin exclusively on rolling cells. The adherent neutrophil support of L-selectin-dependent neutrophil rolling in vivo can promote continuous and augmented leukocyte recruitment at sites of previous neutrophil accumulation. |
| Databáze: | OpenAIRE |
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