The recording and prevalence of Inflammatory bowel disease in girls' primary care medical Spanish records
| Autor: | Belén Castillo-Cano, Elisa Martín-Merino, Mar Martín-Pérez, Dolores Montero-Corominas |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Referral Epidemiology Colonoscopy digestive system 030226 pharmacology & pharmacy Inflammatory bowel disease 03 medical and health sciences 0302 clinical medicine Internal medicine Biopsy medicine Prevalence Electronic Health Records Humans Pharmacology (medical) 030212 general & internal medicine Medical prescription Family history medicine.diagnostic_test Primary Health Care business.industry Pharmacoepidemiology medicine.disease Inflammatory Bowel Diseases digestive system diseases Observational study Female business Rare disease |
| Zdroj: | Pharmacoepidemiology and drug safetyREFERENCES. 29(11) |
| ISSN: | 1099-1557 |
| Popis: | Purpose Inflammatory bowel disease (IBD) recording validation among girls in the Spanish Primary Care Database For Pharmacoepidemiological Research (BIFAP). Methods In this observational study, girls aged 9 to 18 years registered in BIFAP between 2002 and 2016, were followed up until there was a recorded IBD diagnosis or a referral to specialist indicating IBD. Anonymized profiles were reviewed to retrieve diagnosis confirmation (a positive colonoscopy or biopsy, specialist, or physician's comments mentioning the IBD diagnosis) or discarding (negative procedure results, alternative diagnosis, or family history). "possible" IBD were profiles missing that evidence, or had suspected IBD. The prescriptions of intestinal anti-inflammatory agents, azatioprine, and mercaptopurine were collected. The prevalence of IBD was estimated after review. Results Out of 480 634 girls, 323 had a first ever recorded IBD, of which, 37.8% (N = 122) were "confirmed" incident IBD diagnosis, 19.8% (N = 64) discarded and 38.7% (N = 125) "possible" IBD. Additionally, 12 IBD records (3.7%) referred to prevalent IBD. Prescriptions were recorded in 94.3% (confirmed), 63.2% (possible), 83.3% (prevalent), and 3.1% (discarded) IBD cases. Prevalence was 52.83 "confirmed" or 93.58/105 girls when "possible" IBD were added. Conclusions For a third of the girls, the first recorded IBD included evidence confirming the diagnosis while most of those with missing evidence had treatment indicated for IBD. For research focused in sensitivity, an algorithm including "possible" plus "confirmed" episodes is recommended, whereas only "confirmed" to guarantee higher predictive value. Prevalence suggests that IBD is not a rare disease among girls. |
| Databáze: | OpenAIRE |
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