Successful Isavuconazole therapy in a patient with acute invasive fungal rhinosinusitis and acquired immune deficiency syndrome
| Autor: | Yasmina Ahmed, Sean W. Delaney, Alexander Markarian |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Mucorales Antifungal medicine.medical_specialty Pyridines medicine.drug_class 030106 microbiology Immune deficiency syndrome Immunocompromised Host 03 medical and health sciences 0302 clinical medicine Nitriles medicine Humans In patient 030212 general & internal medicine Sinusitis Intensive care medicine Rhinitis Acquired Immunodeficiency Syndrome biology business.industry Mortality rate Mucormycosis Surgical debridement HIV Middle Aged Triazoles medicine.disease biology.organism_classification Dermatology Mycoses Otorhinolaryngology business |
| Zdroj: | American Journal of Otolaryngology. 37:152-155 |
| ISSN: | 0196-0709 |
| DOI: | 10.1016/j.amjoto.2015.12.003 |
| Popis: | Objectives To report a case of acute invasive Mucorales rhinosinusitis in a patient with acquired immune deficiency syndrome and diabetes mellitus. To provide a literature review on the role of Isavuconazole in the management of invasive Mucorales rhinosinusitis. Methods A literature review was conducted on August 9, 2015 using PubMed database. The keywords isavuconazole and invasive fungal rhinosinusitis were employed to identify original scientific manuscripts that describe the use of Isavuconazole in patients with invasive fungal rhinosinusitis or rhinocerebral mucormycosis. Results The initial search yielded 35 articles with only 1 article (case report) describing the clinical use of Isavuconazole in a patient with invasive Mucorales rhinosinusitis. Conclusions Acute invasive fungal rhinosinusitis is a rare, life-threatening infection with mortality rates reported to range from 30–83%. Successful treatment depends on early surgical debridement, systemic anti-fungal therapy, and correction of predisposing conditions. Isavuconazole (Cresemba), a newly approved antifungal, is safe and clinically effective in treating invasive mucormycosis. This important new therapy should be considered for patients with invasive Mucorales rhinosinusitis that is refractory or intolerant to Amphotericin B. |
| Databáze: | OpenAIRE |
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