OxLDL-induced gene expression patterns in CASMC are mimicked in apoE-/- mice aortas
| Autor: | Catherine Stenson-Cox, Timothy O'Brien, Isabella Pörn-Ares, Afshin Samali, Aideen O’Doherty, Janice L. V. Reeve, Mikko P.S. Ares |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Apolipoprotein E
medicine.medical_specialty Programmed cell death Biophysics 030204 cardiovascular system & hematology Biology medicine.disease_cause Biochemistry Fas ligand Muscle Smooth Vascular 03 medical and health sciences Mice 0302 clinical medicine Apolipoproteins E Internal medicine Gene expression medicine Animals Humans Molecular Biology Gene Aorta 030304 developmental biology 0303 health sciences Cell Death Gene Expression Profiling Cell Biology Coronary Vessels Pathophysiology Lipoproteins LDL Oxidative Stress Endocrinology Caspases Immunology Unfolded protein response lipids (amino acids peptides and proteins) Oxidative stress |
| Zdroj: | Biochemical and biophysical research communications. 356(3) |
| ISSN: | 0006-291X |
| Popis: | Oxidized low density lipoprotein (oxLDL) contributes to the pathophysiology of atherosclerosis, partly by altering gene expression in vascular cells. Here, we show 221 genes differentially regulated by oxLDL in coronary artery smooth muscle cells (CASMC), using oligonucleotide microarrays. These genes were classified into 14 functional groups. A comparable gene expression pattern was detected in apoE(-/-) mice. OxLDL induced an oxidative stress response in CASMC, but not the unfolded protein response. OxLDL also caused CASMC death which was accompanied by increased expression of FasL, Bax, and p53 but was caspase-independent. This approach provides further insight into disease pathology and prognosis. (c) 2007 Elsevier Inc. All rights reserved. (Less) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect