Permanent cardiac pacing in children: choosing the optimal pacing site: a multicenter study

Autor: John Papagiannis, Sabrina Tsao, S. A. Clur, Jan Marek, Svjetlana Tisma-Dupanovic, Jan Janoušek, Eric Rosenthal, Andreas Früh, Peter Kubuš, Kelly Nugent, Patrick Frias, Julia Volaufova, Mark K. Friedberg, Jan Elders, Tammo Delhaas, Gunter Kerst, Jan Hendrik Nürnberg, Christopher Wren, Roman Gebauer, Maxime De Guillebon, Frits W. Prinzen, Bert Nagel, Maren Tomaske, Anita Hiippala, Sylvia Krupickova, Javier Ganame, Irene E. van Geldorp, Fulvio Gabbarini
Přispěvatelé: ACS - Amsterdam Cardiovascular Sciences, AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Paediatric Cardiology, MUMC+: MA Arts Assistenten Kindergeneeskunde (9), Fysiologie, Biomedische Technologie, Kindergeneeskunde, RS: CARIM School for Cardiovascular Diseases
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Circulation, 127(5), 613-623. Lippincott Williams and Wilkins
Circulation, 127(5), 613-623. LIPPINCOTT WILLIAMS & WILKINS
ISSN: 0009-7322
Popis: Background— We evaluated the effects of the site of ventricular pacing on left ventricular (LV) synchrony and function in children requiring permanent pacing. Methods and Results— One hundred seventy-eight children (aged R =0.80, P =0.031). Pacing from the RV outflow tract/lateral RV predicted significantly decreased LV function (LV ejection fraction P =0.005), whereas LV apex/LV midlateral wall pacing was associated with preserved LV function (LV ejection fraction ≥55%; odds ratio, 8.26; confidence interval, 1.46–47.62; P =0.018). Presence of maternal autoantibodies, gender, age at implantation, duration of pacing, DDD mode, and QRS duration had no significant impact on LV ejection fraction. Conclusions— The site of ventricular pacing has a major impact on LV mechanical synchrony, efficiency, and pump function in children who require lifelong pacing. Of the sites studied, LV apex/LV midlateral wall pacing has the greatest potential to prevent pacing-induced reduction of cardiac pump function.
Databáze: OpenAIRE