A comparative study of imipenem versus piperacillin plus gentamicin in the initial management of febrile neutropenic patients with haematological malignancies
| Autor: | S. A. Murray, R. Warren, D. G. White, Adrian C. Newland, A. J. Bint, M. J. Leyland, C. Cefai, D. Bareford, N. B. Deaney, Jonathan Cohen, K. F. Bayston |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Microbiology (medical) medicine.medical_specialty Imipenem Neutropenia Adolescent Fever Lymphoma Nausea medicine.medical_treatment Internal medicine polycyclic compounds medicine Humans Pharmacology (medical) Aged Antibacterial agent Piperacillin Pharmacology Chemotherapy Leukemia business.industry Middle Aged medicine.disease Infectious Diseases Anesthesia Vomiting Drug Therapy Combination Gentamicin Gentamicins medicine.symptom business medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 30:843-854 |
| ISSN: | 1460-2091 0305-7453 |
| Popis: | Three-hundred and twelve episodes of fever in 234 neutropenic patients with haematological malignancies were treated empirically with either imipenem or a combination of piperacillin and gentamicin. There were no significant differences in the percentages of patients responding to therapy at either 72 h (59% and 56% of assessable episodes in the imipenem and combination groups respectively) or at the end of treatment (55% and 53% of assessable episodes in the imipenem and combination groups respectively). Patients in the piperacillin plus gentamicin group experienced significantly more renal tubular damage whereas those who received imipenem suffered more nausea or vomiting. We conclude that imipenem monotherapy represents an acceptable alternative to piperacillin plus gentamicin as empirical therapy of the febrile neutropenic patient. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|