Improved biopharmaceutical performance of antipsychotic drug using lipid nanoparticles via intraperitoneal route

Autor:	Hezhong Ouyang, Jinquan Hu, XingYing Qiu, Shaochang Wu, Fudong Guo, Youguo Tan
Rok vydání:	2022
Předmět:	Lipopolysaccharides Biological Products Drug Carriers NF-kappa B Pharmaceutical Science General Medicine Mice Lanosterol Suspensions Cyclooxygenase 2 Olanzapine Delayed-Action Preparations Liposomes Animals Nanoparticles Particle Size Antipsychotic Agents
Zdroj:	Pharmaceutical development and technology. 27(7)
ISSN:	1097-9867
Popis:	This study aims to develop, characterize, and examine olanzapine-loaded solid lipid nanocarriers (OLAN-SLNs) for effective brain delivery. OLAN has poor water solubility and low penetration through blood-brain barrier (BBB). Herein, OLAN-SLNs were fabricated using high-pressure homogenization (HPH) method followed by their investigation for particle properties. Moreover
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cd86cb12eba9ffa27bff524066ae0e https://pubmed.ncbi.nlm.nih.gov/36124550 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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