Is the optimal pH for membrane fusion in host cells by avian influenza viruses related to host range and pathogenicity?
Autor: | Keita Matsuno, Yoshihiro Sakoda, Kazuki Nagaya, Masatoshi Okamatsu, Hiroshi Kida, Tomokazu Tamura, Yurie Motohashi, Takahiro Hiono |
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Rok vydání: | 2015 |
Předmět: |
0301 basic medicine
animal structures viruses Virulence Hemagglutinin (influenza) Hemagglutinin Glycoproteins Influenza Virus Biology medicine.disease_cause Virus Replication H5N1 genetic structure Membrane Fusion Virus Host Specificity Microbiology Cell Line 03 medical and health sciences Virology Influenza A virus medicine Animals Phylogeny Poultry Diseases Influenza A Virus H5N1 Subtype virus diseases Lipid bilayer fusion General Medicine Hydrogen-Ion Concentration Influenza A virus subtype H5N1 030104 developmental biology Ducks Viral replication Influenza in Birds biology.protein Influenza A Virus H5N2 Subtype Chickens |
Zdroj: | Archives of virology. 161(8) |
ISSN: | 1432-8798 |
Popis: | Influenza viruses isolated from wild ducks do not replicate in chickens. This fact is not explained solely by the receptor specificity of the hemagglutinin (HA) from such viruses for target host cells. To investigate this restriction in host range, the fusion activities of HA molecules from duck and chicken influenza viruses were examined. Influenza viruses A/duck/Mongolia/54/2001 (H5N2) (Dk/MNG) and A/chicken/Ibaraki/1/2005 (H5N2) (Ck/IBR), which replicate only in their primary hosts, were used. The optimal pH for membrane fusion of Ck/IBR was 5.9, higher than that of Dk/MNG at 4.9. To assess the relationship between the optimal pH for fusion and the host range of avian influenza viruses, the optimal pH for fusion of 55 influenza virus strains isolated from ducks and chickens was examined. No correlation was found between the host range and optimal pH for membrane fusion by the viruses, and this finding applied also to the H5N1 highly pathogenic avian influenza viruses. The optimal pH for membrane fusion for avian influenza viruses was shown to not necessarily be correlated with their host range or pathogenicity in ducks and chickens. |
Databáze: | OpenAIRE |
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