Phosphorus-induced nephrocalcinosis in female rats: a study on regression and clinical abnormalities
| Autor: | S.J.A.J. Soeterboek, A. C. Beynen, J. Ritskes-Hoitinga, A. G. Lemmens |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Kidney General Veterinary business.industry Phosphorus Body Weight Remission Spontaneous chemistry.chemical_element Rats Inbred Strains Calcium Body weight medicine.disease Rats Nephrocalcinosis Endocrinology medicine.anatomical_structure chemistry Internal medicine medicine Animals Phosphorus Dietary Female Animal Science and Zoology business |
| Zdroj: | Laboratory Animals. 25:258-262 |
| ISSN: | 1758-1117 0023-6772 |
| Popis: | The question addressed was whether pre-established phosphorus (P)-induced nephrocalcinosis would regress after dietary P restriction. Female rats were fed purified diets containing either 0·2% (w/w) P(low P) or 0·6% P (high P). After 29 days, the high-P diet had caused massive nephrocalcinosis as demonstrated chemically (by the analysis of calcium in kidney) and histologically Jby inspection of kidney sections stained for calcium phosphate deposits). Switching rats from the high P to the low P diet did not result in a decrease in the degree of nephrocalcinosis within 91 days. Thus, P-induced nephrocalcinosis may not regress upon subsequent P restriction. Rats that had been fed either the 0·2 or 0·6% P diet for 56 days were examined clinically with respect to 14 selected variables. None of the variables discriminated between rats with or without nephrocalcinosis. This might imply that P-induced nephrocalcinosis in female rats does not cause significant discomfort. |
| Databáze: | OpenAIRE |
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