The 'Dose-Effect' Relationship Between 25-Hydroxyvitamin D and Muscle Strength in Hemodialysis Patients Favors a Normal Threshold of 30 ng/mL for Plasma 25-Hydroxyvitamin D
| Autor: | Jacques Ollier, Philippe Giaime, Julien Astier, Marianne Serveaux, Jean-François Landrier, Jérôme Sampol, Jean Gugliotta, Julien Cohen, Patrice Darmon, Hélène Sichez, Stanislas Bataille |
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| Přispěvatelé: | Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION ), Nutrition humaine et lipides : Biodisponibilité, métabolisme et régulation, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Recherche Agronomique (INRA)-Université de Provence - Aix-Marseille 1-IFR125-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition, obésité et risque thrombotique (NORT), Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION)-Assistance Publique - Hôpitaux de Marseille (APHM) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment [SDV]Life Sciences [q-bio] Population 030232 urology & nephrology Nutritional Status Medicine (miscellaneous) Body Mass Index 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Renal Dialysis Internal medicine Hand strength medicine Vitamin D and neurology Humans Prealbumin 030212 general & internal medicine Vitamin D education ComputingMilieux_MISCELLANEOUS Aged Aged 80 and over Creatinine education.field_of_study Nutrition and Dietetics Dose-Response Relationship Drug Hand Strength business.industry [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Dose–response relationship Cross-Sectional Studies Nutrition Assessment Endocrinology chemistry Nephrology Dietary Supplements Body Composition Linear Models Muscle strength Female Hemodialysis business Body mass index [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Journal of Renal Nutrition Journal of Renal Nutrition, WB Saunders, 2016, 26 (1), pp.45-52. ⟨10.1053/j.jrn.2015.08.007⟩ Journal of Renal Nutrition, 2016, 26 (1), pp.45-52. ⟨10.1053/j.jrn.2015.08.007⟩ HAL Journal of Renal Nutrition, WB Saunders, 2016, 26 (1), pp.45-52 Journal of Renal Nutrition, 2016, 26 (1), pp.45-52 |
| ISSN: | 1051-2276 1532-8503 |
| DOI: | 10.1053/j.jrn.2015.08.007⟩ |
| Popis: | International audience; Objective: Muscle strength is weakened in maintenance hemodialysis patients. Strength is both a measure of a functional parameter and of frailty as it is independently associated with mortality. In the general population, observational studies show that plasma 25-hydroxyvitamin D (25[OH]D) is positively correlated with muscle strength and function. We analyzed the determinants of muscle strength measured by handgrip and 25(OH)D in a maintenance hemodialysis population. Methods: In this observational cross-sectional study, data from all hemodialysis patients from our nephrology department were recorded in July 2014. Daily nutritional oral intake, handgrip strength, body composition measured by bioimpedancemetry analysis, as well as biological and dialysis parameters, were obtained from medical files. We used a linear regression model to assess nutritional, biological, and dialysis parameters as well as body composition associated with handgrip strength. Results: The median age (interquartile range) of the 130 included patients was 77.3 (69.5-84.7) years, 57.7% were men, and 50.8% had diabetes mellitus. Median handgrip strength value (interquartile range) was 14.3 (10.6-22.2) kg. In univariate analyses, the factors associated with handgrip strength were age, gender, albumin, transthyretin, predialysis creatinine and urea, normalized protein nitrogen appearance, lean mass, and muscle mass measured by bioimpedancemetry analysis as well as phase angle, and 25(OH)D. In multivariate analyses, lower age, male gender, higher albumin, higher muscle mass, and 25(OH)D level >= 30 ng/mL were independently correlated with muscle strength measured by handgrip. Conclusions: This study found a positive correlation between plasma 25(OH)D and muscle strength measured by handgrip in hemodialysis patients. We report a "dose-effect'' relationship between 25(OH)D and handgrip strength under 30 ng/mL, which is no more present above 30 ng/mL. Prospective randomized studies are needed to prove that supplementation with cholecalciferol, leading to 25(OH)D levels >= 30 ng/mL, improves muscle strength in hemodialysis patients. ( |
| Databáze: | OpenAIRE |
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