The role of microRNAs on doxorubicin drug resistance in breast cancer
| Autor: | Fatemeh Zahedipour, Khadijeh Jamialahmadi, Gholamreza Karimi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmaceutical Science
Breast Neoplasms ATP-binding cassette transporter Drug resistance 03 medical and health sciences 0302 clinical medicine Breast cancer Cancer stem cell microRNA Humans Medicine Doxorubicin Molecular Targeted Therapy Epithelial–mesenchymal transition 030304 developmental biology Pharmacology 0303 health sciences Antibiotics Antineoplastic business.industry Autophagy medicine.disease Gene Expression Regulation Neoplastic MicroRNAs Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer research ATP-Binding Cassette Transporters business medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 73:997-1006 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1093/jpp/rgaa031 |
| Popis: | Objectives Resistance to chemotherapeutic drugs is a serious challenge for effective therapy of cancers. Doxorubicin is a drug which is typically used for breast cancer treatment. Several mechanisms are involved in resistance to doxorubicin including overexpression of ATP-binding cassette (ABC) transporters, altering apoptosis, autophagy and cell cycle arrest. In this review, we focus on the potential effects of microRNAs on doxorubicin resistance in breast cancer. Methods Literature review focusing on the ‘microRNAs and doxorubicin drug resistance in breast cancer’ was conducted comprehensively. The search was performed in PubMed, Scopus, Google and Google Scholar databases and reference lists of relevant articles were also included. Key findings MicroRNAs play essential role in resistance of breast cancer to doxorubicin by affecting several key cellular pathways, including overexpression of ABC transporters, altering apoptosis, autophagy and cell signaling pathways, cell cycle arrest, epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). Conclusions Cancer treatment methods are moving from conventional therapies to targeted therapies such as using microRNAs. MiRNAs can act as regulatory molecules to overcome breast cancer doxorubicin resistance by controlling the expression levels of genes involved in different cellular pathways. Thus, exact elucidation of their role in different cellular processes can help overcome the breast cancer development and drug resistance. |
| Databáze: | OpenAIRE |
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