A Review of the Role of Hypoxia in Radioresistance in Cancer Therapy
| Autor: | Anne-Sophie Wozny, Sandrine Sotton, Claire Rodriguez-Lafrasse, Safa Louati, Benoîte Méry, Elise Rowinski, Wafa Bouleftour, Pablo Moreno-Acosta, Nicolas Magné |
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| Přispěvatelé: | Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_treatment Cancer therapy Disease Radiation Tolerance Metastasis 03 medical and health sciences 0302 clinical medicine Radioresistance Neoplasms medicine Humans Treatment resistance Adverse effect Hypoxia Review Articles 030304 developmental biology [PHYS]Physics [physics] 0303 health sciences Radiotherapy business.industry General Medicine Hypoxia (medical) medicine.disease Cancer Familial with In Vitro Radioresistance 3. Good health Radiation therapy 030220 oncology & carcinogenesis Cancer research Female Hypoxia-Inducible Factor 1 medicine.symptom business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research Medical Science Monitor Medical Science Monitor, 2021, 27, pp.e934116. ⟨10.12659/msm.934116⟩ |
| ISSN: | 1643-3750 1234-1010 |
| Popis: | International audience; Hypoxia involves neoplastic cells. Unlike normal tissue, solid tumors are composed of aberrant vasculature, leading to a hypoxic microenvironment. Hypoxia is also known to be involved in both metastasis initiation and therapy resistance. Radiotherapy is the appropriate treatment in about half of all cancers, but loco-regional control failure and a disease recurrence often occur due to clinical radioresistance. Hypoxia induces radioresistance through a number of molecular pathways, and numerous strategies have been developed to overcome this. Nevertheless, these strategies have resulted in disappointing results, including adverse effects and limited efficacy. Additional clinical studies are needed to achieve a better understanding of the complex hypoxia pathways. This review presents an update on the mechanisms of hypoxia in radioresistance in solid tumors and the potential therapeutic solutions |
| Databáze: | OpenAIRE |
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