Overexpression of Interleukin 2 Receptor, Thymidine Kinase and Immunoglobulin-Associated Alpha-1 Messenger RNA in a Clinical Case of Enzootic Bovine Leukosis
| Autor: | Michihito Tagawa, Yoshiyasu Kobayashi, Mohammad Monir Tawfeeq, Kazuya Sugimoto, Yuuki Itoh, Hisashi Inokuma |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Interleukin 2
Thymidine kinase activity Biopsy Fine-Needle Thymidine Kinase Fatal Outcome Gene expression Biomarkers Tumor medicine Animals RNA Messenger Lactate Dehydrogenases DNA Primers General Veterinary Bovine leukemia virus biology Reverse Transcriptase Polymerase Chain Reaction Receptors Interleukin-2 Enzootic Bovine Leukosis biology.organism_classification medicine.disease Molecular biology Lymphoma Thymidine kinase Cancer research Cattle Female Lymph Nodes Lymph CD79 Antigens medicine.drug |
| Zdroj: | Journal of Veterinary Medical Science. 74:1203-1206 |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.12-0100 |
| Popis: | A 49-month-old Holstein cow with anorexia, tachypnea, enlarged peripheral lymph nodes, and difficulty standing up was suspected of bovine leukosis. Hematological examination revealed lymphocytosis with the presence of neoplastic cells. Increased total lactate dehydrogenase (LDH) activity, isozymes of LDH-2 and LDH-3 activities and thymidine kinase activity were observed. Cytological findings of fine needle aspiration of subiliac lymph nodes indicated lymphosarcoma. Histopathology and antibody analysis confirmed the diagnosis of enzootic bovine leukosis, a B-cell bovine lymphoma caused by bovine leukemia virus. Gene expressions known as biomarkers of hematopoietic neoplasia in human were also examined in the present case. Increased messenger RNA expression of interleukin 2 receptor, thymidine kinase, and immunoglobulin-associated alpha-1 was observed in the case animal. |
| Databáze: | OpenAIRE |
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