Melatonin Prevents Early but Not Delayed Ventricular Fibrillation in the Experimental Porcine Model of Acute Ischemia

Autor: Pyotr G. Platonov, A O Ovechkin, Darya S. Khramova, Natalya J. Mikhaleva, Marina M. Demidova, Jan E. Azarov, A. S. Tsvetkova, O G Bernikova
Jazyk: angličtina
Rok vydání: 2020
Předmět:
pig
medicine.medical_specialty
Swine
Ischemia
Myocardial Ischemia
melatonin
ischemia
030204 cardiovascular system & hematology
Catalysis
Article
lcsh:Chemistry
Inorganic Chemistry
Melatonin
03 medical and health sciences
0302 clinical medicine
depolarization
Internal medicine
medicine
Repolarization
Animals
cardiovascular diseases
Myocardial infarction
Interventricular septum
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
repolarization
business.industry
Organic Chemistry
Central Nervous System Depressants
General Medicine
medicine.disease
ventricular fibrillation
Computer Science Applications
Electrophysiological Phenomena
Oxidative Stress
medicine.anatomical_structure
lcsh:Biology (General)
lcsh:QD1-999
Coronary occlusion
Ventricular fibrillation
Acute Disease
Cardiology
Cardiac Electrophysiology
business
030217 neurology & neurosurgery
Ex vivo
medicine.drug
Zdroj: International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences, Vol 22, Iss 328, p 328 (2021)
ISSN: 1422-0067
Popis: Antiarrhythmic effects of melatonin have been demonstrated ex vivo and in rodent models, but its action in a clinically relevant large mammalian model remains largely unknown. Objectives of the present study were to evaluate electrophysiological and antiarrhythmic effects of melatonin in a porcine model of acute myocardial infarction. Myocardial ischemia was induced by 40-min coronary occlusion in 25 anesthetized pigs. After ischemia onset, 12 animals received melatonin (4 mg/kg). 48 intramyocardial electrograms were recorded from left ventricular wall and interventricular septum (IVS). In each lead, activation time (AT) and repolarization time (RT) were determined. During ischemia, ATs and dispersion of repolarization (DOR = RTmax &minus
RTmin) increased reaching maximal values by 3&ndash
5 and 20&ndash
25 min, respectively. Ventricular fibrillation (VF) incidence demonstrated no relations to redox state markers and was associated with increased DOR and delayed ATs (specifically, in an IVS base, an area adjacent to the ischemic zone) (p = 0.031). Melatonin prevented AT increase in the IVS base, (p <
0.001) precluding development of early VF (1&ndash
5 min, p = 0.016). VF occurrence in the delayed phase (17&ndash
40 min) where DOR was maximal was not modified by melatonin. Thus, melatonin-related enhancement of activation prevented development of early VF in the myocardial infarction model.
Databáze: OpenAIRE
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