Polyketide and Prenylxanthone Derivatives from the Endophytic Fungus Aspergillus sp. TJ23
| Autor: | Kun Tu, Qianqian Xu, Yonghui Zhang, Jianping Wang, Hucheng Zhu, Chunmei Chen, Wenya Feng, Junjun Liu, Yuben Qiao, Yongbo Xue, Li Tao |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Circular dichroism
Spectrometry Mass Electrospray Ionization Magnetic Resonance Spectroscopy Stereochemistry Cell Survival Xanthones Molecular Conformation Bioengineering 010402 general chemistry 01 natural sciences Biochemistry Polyketide chemistry.chemical_compound Cell Line Tumor Bioassay Humans Molecular Biology Aspergillus Ergosterol biology Strain (chemistry) 010405 organic chemistry Chemistry Circular Dichroism Biological activity General Chemistry General Medicine biology.organism_classification In vitro 0104 chemical sciences Polyketides Molecular Medicine |
| Zdroj: | Chemistrybiodiversity. 15(12) |
| ISSN: | 1612-1880 |
| Popis: | Eight secondary metabolites, including a new polyketide, named asperetide (1) and a new prenylxanthone derivative, called asperanthone (4), and six known compounds, (S)-3-butyl-7-methoxyphthalide (2), ruguloxanthone C (3), tajixanthone hydrate (5), tajixanthone methanoate (6), salimyxin B (7), and ergosterol (8), were isolated and identified from the medicinal plant-derived fungus, Aspergillus sp. TJ23. The new structures and their absolute configurations were elucidated via multiple methods, including 1D- and 2D-NMR, HR-ESI-MS, UV, IR, and the electronic circular dichroism (ECD) calculations. All of the isolates were characterized from the strain for the first time. The in vitro bioassay showed that compounds 3-5 and 8 exerted inhibitory activities against five cancer cell lines (B16, MDA-MB-231, 4T1, HepG2, and LLC) with IC50 values ranging from 5.13 to 36.8 μm. |
| Databáze: | OpenAIRE |
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