Risks associated with the stroke predisposition at young age: facts and hypotheses in light of individualized predictive and preventive approach
| Autor: | Olga Golubnitschaja, Vladimir Rohan, Ondrej Topolcan, Smit Mahajani, Martin Pesta, Libuše Čeledová, Jiri Polivka |
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| Rok vydání: | 2019 |
| Předmět: |
Gerontology
business.industry Health Policy Biochemistry (medical) Review 030204 cardiovascular system & hematology Overweight medicine.disease Flammer syndrome Substance abuse 03 medical and health sciences 0302 clinical medicine Drug Discovery medicine Genetic predisposition medicine.symptom Young adult Risk assessment business Stroke 030217 neurology & neurosurgery Sedentary lifestyle |
| Zdroj: | The EPMA journal. 10(1) |
| ISSN: | 1878-5077 |
| Popis: | Stroke is one of the most devastating pathologies of the early twenty-first century demonstrating 1-month case-fatality rates ranging from 13 to 35% worldwide. Though the majority of cases do occur in individuals at an advanced age, a persistently increasing portion of the patient cohorts is affected early in life. Current studies provide alarming statistics for the incidence of “young” strokes including adolescents. Young stroke is a multifactorial disease involving genetic predisposition but also a number of modifiable factors, the synergic combination of which potentiates the risks. The article analyzes the prevalence and impacts of “traditional” risk factors such as sedentary lifestyle, smoking, abnormal alcohol consumption, drug abuse, overweight, hypertension, abnormal sleep patterns, and usage of hormonal contraceptives, among others. Further, less explored risks such as primary vascular dysregulation and associated symptoms characteristic for Flammer syndrome (FS) are considered, and the relevance of the FS phenotype for the stroke predisposition at young age is hypothesized. Considering the high prevalence of known genetic and modifiable risk factors in the overall predisposition to the young stroke, the risk mitigating measures are recommended including innovative screening programs by application of specialized questionnaires and biomarker panels as well as educational programs adapted to the target audiences such as children, adolescents, and young adults. |
| Databáze: | OpenAIRE |
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