Primary mesenteric sarcomas: Collaborative experience from the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)
| Autor: | Marco Fiore, Hannah L Tattersall, Emily Ryon, Kenneth Cardona, Rachel M. Lee, Samuel J Ford, James Glasbey, Giovanni Grignani, David E. Gyorki, Jose Antonio Peña Gonzalez, Sanjay P. Bagaria, Francesco Tolomeo, Raza Sayyed, Rebecca A. Gladdy, Caroline Evenden, Yvonne Schrage, Alessandro Gronchi, Marko Novak, Fabio Tirotta, Neha Goel, Anant Desai, Winan J. van Houdt, James Hodson, Ana Belen Martin Arnau, William W. Tseng, Carolyn Nessim, Max Almond, Jos A. van der Hage |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty sarcoma surgery 03 medical and health sciences 0302 clinical medicine medicine Retroperitoneal sarcoma Humans Mesentery mesenteric soft tissue sarcoma Retroperitoneal Neoplasms Survival rate Aged Retrospective Studies Tumor size business.industry Primary resection Soft tissue General Medicine Middle Aged medicine.disease Prognosis Survival Rate Oncology 030220 oncology & carcinogenesis Resection margin Extensive resection 030211 gastroenterology & hepatology Female Sarcoma Radiology Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Journal of Surgical Oncology. WILEY Journal of Surgical Oncology JOURNAL OF SURGICAL ONCOLOGY r-IIB SANT PAU: Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Institut dInvestigació Biomèdica Sant Pau (IIB Sant Pau) r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 0022-4790 |
| Popis: | Background Primary mesenteric soft tissue sarcomas (STS) are rare and limited evidence is available to inform management. Surgical resection is challenging due to the proximity of vital structures and a need to preserve enteric function. Objectives To determine the overall survival (OS) and recurrence-free survival (RFS) for patients undergoing primary resection for mesenteric STS. Methods The Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) is an intercontinental collaborative comprising specialist sarcoma centers. Data were collected retrospectively for all patients with mesenteric STS undergoing primary resection between 2000 and 2019. Results Fifty-six cases from 15 institutions were included. The spectrum of pathology was similar to the retroperitoneum, although of a higher grade. R0/R1 resection was achieved in 87%. Median OS was 56 months. OS was significantly shorter in higher-grade tumors (p = .018) and extensive resection (p < .001). No significant association between OS and resection margin or tumor size was detected. Rates of local recurrence (LR) and distant metastases (DM) at 5 years were 60% and 41%, respectively. Liver metastases were common (60%), reflecting portal drainage of the mesentery. Conclusion Primary mesenteric sarcoma is rare, with a modest survival rate. LR and DM are frequent events. Liver metastases are common, highlighting the need for surveillance imaging. |
| Databáze: | OpenAIRE |
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