Egg desiccation leads to dehydration and enhanced innate immunity in python embryos
Autor: | George A. Brusch, Dale F. DeNardo |
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Rok vydání: | 2019 |
Předmět: |
0106 biological sciences
0301 basic medicine Embryo Nonmammalian Gene Transfer Horizontal Immunology Organism Hydration Status 010603 evolutionary biology 01 natural sciences Immunomodulation 03 medical and health sciences Antaresia childreni Immune system Animals Desiccation Organism Ovum Life Cycle Stages Innate immune system Dehydration biology Gene Expression Regulation Developmental Embryo biochemical phenomena metabolism and nutrition biology.organism_classification Embryonic stem cell Immunity Innate Cell biology Boidae 030104 developmental biology Animals Newborn Female Immunocompetence Energy Metabolism Developmental Biology |
Zdroj: | Developmental & Comparative Immunology. 90:147-151 |
ISSN: | 0145-305X |
Popis: | The immune system is essential for survival and its performance can vary depending on the physiological state of the organism. Much of the current research into immune function dynamics has examined newborn to adult life stages, despite previous studies documenting physiological responses in embryos to environmental stimuli. While energy balance has been the predominant focus as the driver of changes in immune function, recent research has found a positive relationship between dehydration and innate immune performance in adult reptiles. We expanded the understanding of this relationship by examining trans-generational immune effects of female dehydration as well as the effects of egg desiccation on embryonic hydration state and innate immunity using Children's pythons, Antaresia childreni. We used a 2 × 2 experiment with hydrated or dehydrated mothers and eggs either incubated under continuous optimal conditions or experiencing desiccating conditions for 24 h. Our results demonstrate that, similar to adults, embryos enhance some metrics of innate immunity when they are dehydrated. |
Databáze: | OpenAIRE |
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