Causal contribution and dynamical encoding in the striatum during evidence accumulation
| Autor: | Carlos D. Brody, Timothy D. Hanks, Michael M. Yartsev, Alice M. Yoon |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
QH301-705.5 Science striatum Models Neurological Sensation Posterior parietal cortex Action Potentials Striatum Optogenetics Biology Basic Behavioral and Social Science General Biochemistry Genetics and Molecular Biology decision making neuroscience 03 medical and health sciences 0302 clinical medicine Models Encoding (memory) Task Performance and Analysis Behavioral and Social Science Biological neural network Animals rat Biology (General) Neurons Behavior General Immunology and Microbiology Behavior Animal Animal General Neuroscience Neurosciences General Medicine Rats Neostriatum Brain region Electrophysiology 030104 developmental biology Neurological Medicine Anterior dorsal Mental health Biochemistry and Cell Biology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | eLife, Vol 7 (2018) |
| Popis: | A broad range of decision-making processes involve gradual accumulation of evidence over time, but the neural circuits responsible for this computation are not yet established. Recent data indicate that cortical regions that are prominently associated with accumulating evidence, such as the posterior parietal cortex and the frontal orienting fields, may not be directly involved in this computation. Which, then, are the regions involved? Regions that are directly involved in evidence accumulation should directly influence the accumulation-based decision-making behavior, have a graded neural encoding of accumulated evidence and contribute throughout the accumulation process. Here, we investigated the role of the anterior dorsal striatum (ADS) in a rodent auditory evidence accumulation task using a combination of behavioral, pharmacological, optogenetic, electrophysiological and computational approaches. We find that the ADS is the first brain region known to satisfy the three criteria. Thus, the ADS may be the first identified node in the network responsible for evidence accumulation. |
| Databáze: | OpenAIRE |
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