Anti-stress effects of the glucagon-like peptide-1 receptor agonist liraglutide in zebrafish
| Autor: | Adriane R. Rosa, Ana Paula Herrmann, Ricieri Mocelin, Rosane Gomez, P.r. Bertelli, Angelo Luis Stapassoli Piato, Matheus Marcon, Adrieli Sachett |
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| Rok vydání: | 2021 |
| Předmět: |
Agonist
Male medicine.drug_class Oxidative phosphorylation Pharmacology Glucagon-Like Peptide-1 Receptor 03 medical and health sciences 0302 clinical medicine Medicine Animals Humans Hypoglycemic Agents Chronic stress Receptor Zebrafish Biological Psychiatry Glucagon-like peptide 1 receptor biology business.industry Liraglutide Brain biology.organism_classification Phenotype 030227 psychiatry Oxidative Stress Female business Stress Psychological medicine.drug |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 111 |
| ISSN: | 1878-4216 |
| Popis: | Stress-related disorders are extremely harmful and cause significant impacts on the individual and society. Despite the limited evidence regarding glucagon-like peptide-1 receptor (GLP-1R) and mental disorders, a few clinical and preclinical studies suggest that modulating this system could improve symptoms of stress-related disorders. This study aimed to investigate the effects of liraglutide, a GLP-1R agonist, on neurobehavioral phenotypes and brain oxidative status in adult zebrafish. Acute liraglutide promoted anxiolytic-like effects in the light/dark test, while chronic treatment blocked the impact of unpredictable chronic stress on behavioral and physiological parameters. Taken together, our study demonstrates that liraglutide is active on zebrafish brain and may counteract some of the effects induced by stress. More studies are warranted to further elucidate the potential of GLP-1R agonists for the management of brain disorders. |
| Databáze: | OpenAIRE |
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