Co-variation between glucocorticoids, behaviour and immunity supports the pace-of-life syndrome hypothesis: an experimental approach
Autor: | Rupert Palme, Chloé Monestier, Marie-Line Maublanc, Marine Wasniewski, Benoit Rannou, Guillaume Le Loc’h, Typhaine Lavabre, Emmanuelle Gilot-Fromont, Hélène Verheyden, Luca Börger, Benjamin Rey, Jeffrey Carbillet, Nicolas Cebe, Jean-Luc Rames |
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Přispěvatelé: | Unité de recherche Comportement et Ecologie de la Faune Sauvage (CEFS), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), University of Veterinary Medicine [Vienna] (Vetmeduni), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, Bankiva, Swansea University, Centre Régional d'Exploration Fonctionnelle et Ressources Expérimentales (CREFRE), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Inovie Vet, Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire de la rage et de la faune sauvage de Nancy (LRFSN), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), SEGUIN, Nathalie, Marchal-Mauer, Sophie, Dynamiques eco-évolutives des maladies infectieuses - - ECOFECT2011 - ANR-11-LABX-0048 - LABX - VALID, PROJET AVENIR LYON SAINT-ETIENNE - - Avenir L.S.E.2011 - ANR-11-IDEX-0007 - IDEX - VALID, ANR-11-LABX-0048,ECOFECT,Dynamiques eco-évolutives des maladies infectieuses(2011), ANR-11-IDEX-0007,Avenir L.S.E.,PROJET AVENIR LYON SAINT-ETIENNE(2011), Laboratoire de Lyon [ANSES] |
Jazyk: | angličtina |
Rok vydání: | 2022 |
Předmět: |
0106 biological sciences
Hydrocortisone [SDV.IMM] Life Sciences [q-bio]/Immunology animal diseases Adaptive immunity Physiology Inflammation Animals Wild Biology Stress 010603 evolutionary biology 01 natural sciences General Biochemistry Genetics and Molecular Biology Cortisol 03 medical and health sciences Immune system Capreolus Immunity biology.animal medicine Animals Glucocorticoids General Environmental Science 030304 developmental biology Innate immunity 0303 health sciences Innate immune system [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health General Immunology and Microbiology Ecology Deer [SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health General Medicine biochemical phenomena metabolism and nutrition biology.organism_classification Acquired immune system Coping style 3. Good health Vaccination Roe deer bacteria [SDV.IMM]Life Sciences [q-bio]/Immunology medicine.symptom General Agricultural and Biological Sciences |
Zdroj: | Proceedings of the Royal Society B: Biological Sciences Proceedings of the Royal Society B: Biological Sciences, 2022, 289 (1975), pp.20220464. ⟨10.1098/rspb.2022.0464⟩ Proc Biol Sci |
ISSN: | 0962-8452 1471-2954 |
Popis: | The biomedical literature has consistently highlighted that long-term elevation of glucocorticoids might impair immune functions, while short-term elevation might enhance them. In contrast, in wild and free-ranging animals, patterns are less clear. In the present study, we explored the stress-immunity relationship in controlled conditions, taking into account the potential effects of behavioural profiles. Thirteen captive roe deer (Capreolus capreolus) were monitored over an eight-week period encompassing two capture events. We assessed how changes in baseline faecal cortisol metabolite (FCM) concentrations following a standardised capture protocol and vaccination affected changes in thirteen immune parameters of the innate and adaptive immunity, and whether behavioural profiles were linked to changes in baseline FCM levels and immune parameters. We found that individuals showing an increase in baseline FCM levels over time also exhibited an increase in immunity, for both the innate and adaptive immunity and were characterised by more reactive behavioural profiles (as indicated by low activity levels, docility to manipulation and neophilia). Consequently, our results suggest that immunity of large mammals may be influenced by their stress level, but also by their behavioural profiles, as it is predicted by the pace-of-life syndrome hypothesis. Our analysis therefore highlights the need to consider co-variations between behavioural profiles, immunity and stress hormones in order to gain a better understanding of the unexplained among-individual variability in the glucocorticoids-immunity relationships observed in wildlife, as they may be underpinned by different life-history strategies. |
Databáze: | OpenAIRE |
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