[18F]-labeled 2-methoxyphenylpiperazine derivative as a potential brain positron emission tomography imaging agent
| Autor: | Tiantian Mou, Yunchuan Ma, Cheng Peng, Xianzhong Zhang, Wenjiang Yang |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Fluorine Radioisotopes
Biodistribution Metabolic Clearance Rate Analytical chemistry Sensitivity and Specificity Piperazines Mice chemistry.chemical_compound medicine Brain positron emission tomography Animals Tissue Distribution Brain uptake Radiation medicine.diagnostic_test Chemistry Radiochemistry Brain Reproducibility of Results Imaging agent Organ Specificity Positron emission tomography Positron-Emission Tomography Yield (chemistry) Feasibility Studies Radiopharmaceuticals Derivative (chemistry) |
| Zdroj: | Applied Radiation and Isotopes. 67:2013-2018 |
| ISSN: | 0969-8043 |
| DOI: | 10.1016/j.apradiso.2009.07.012 |
| Popis: | This study reports the synthesis and characterization of N-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl-4-[(18)F]fluorobenzamide ([(18)F]MPP3F). The total reaction time for [(18)F]MPP3F, including final high-performance liquid chromatography purification, was about 3h. Typical decay-corrected radiochemical yield was 18.4+/-3.1%. The radiochemical purity was98%. Biodistribution in mice showed that [(18)F]MPP3F is a potential brain imaging agent for positron emission tomography. The brain uptake of [(18)F]MPP3F was 6.59+/-0.77% Injected Dose/g at 2 min post-injection time. A brain-to-blood ratio of 3.67 was reached at 15 min after injection. |
| Databáze: | OpenAIRE |
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