Identification of c-MYC as a target of the APC pathway
| Autor: | Heiko Hermeking, Leigh Zawel, Bert Vogelstein, Luis T. da Costa, Andrew B. Sparks, Patrice J. Morin, Kenneth W. Kinzler, Carlo Rago, Tong-Chuan He |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Beta-catenin
Genes APC Tumor suppressor gene Transcription Genetic Adenomatous polyposis coli Adenomatous Polyposis Coli Protein Genes myc Biology Cell Line Proto-Oncogene Proteins c-myc Genes Reporter AXIN1 Humans Promoter Regions Genetic Transcription factor beta Catenin Regulation of gene expression Multidisciplinary Binding Sites Oncogene Gene Expression Regulation Neoplastic Cytoskeletal Proteins Catenin Mutation biology.protein Cancer research Trans-Activators Colorectal Neoplasms TCF Transcription Factors HT29 Cells Transcription Factor 7-Like 2 Protein Signal Transduction Transcription Factors |
| Zdroj: | Science (New York, N.Y.). 281(5382) |
| ISSN: | 0036-8075 |
| Popis: | The adenomatous polyposis coli gene ( APC ) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of APC cause aberrant accumulation of β-catenin, which then binds T cell factor–4 (Tcf-4), causing increased transcriptional activation of unknown genes. Here, the c- MYC oncogene is identified as a target gene in this signaling pathway. Expression of c- MYC was shown to be repressed by wild-type APC and activated by β-catenin, and these effects were mediated through Tcf-4 binding sites in the c- MYC promoter. These results provide a molecular framework for understanding the previously enigmatic overexpression of c-MYC in colorectal cancers. |
| Databáze: | OpenAIRE |
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