Human induced pluripotent stem cell-derived vascular smooth muscle cells: differentiation and therapeutic potential
| Autor: | Søren P. Sheikh, Tilde Eskildsen, Sohrab Ayoubi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Myocytes Cardiac/drug effects Pathology medicine.medical_specialty Cell type Vascular smooth muscle Physiology medicine.medical_treatment Induced Pluripotent Stem Cells Myocytes Smooth Muscle Regenerative medicine Muscle Smooth Vascular Cell therapy 03 medical and health sciences Induced Pluripotent Stem Cells/cytology Physiology (medical) Cell Lineage/physiology Journal Article Vascular smooth muscle cells Regeneration Medicine Animals Humans Cell Lineage Myocytes Cardiac Induced pluripotent stem cell Stem cell therapy HiPSC business.industry Drug discovery Myocytes Smooth Muscle/metabolism Regeneration (biology) Cell Differentiation Stem-cell therapy 030104 developmental biology Muscle Smooth Vascular/cytology Differentiation Cardiology and Cardiovascular Medicine business Neuroscience |
| Zdroj: | Ayoubi, S, Sheikh, S P & Eskildsen, T V 2017, ' Human induced pluripotent stem cell-derived vascular smooth muscle cells : differentiation and therapeutic potential ', Cardiovascular Research, vol. 113, no. 11, pp. 1282-1293 . https://doi.org/10.1093/cvr/cvx125 |
| ISSN: | 1755-3245 |
| Popis: | Cardiovascular diseases remain the leading cause of death worldwide and current treatment strategies have limited effect of disease progression. It would be desirable to have better models to study developmental and pathological processes and model vascular diseases in laboratory settings. To this end, human induced pluripotent stem cells (hiPSCs) have generated great enthusiasm, and have been a driving force for development of novel strategies in drug discovery and regenerative cell-therapy for the last decade. Hence, investigating the mechanisms underlying the differentiation of hiPSCs into specialized cell types such as cardiomyocytes, endothelial cells, and vascular smooth muscle cells (VSMCs) may lead to a better understanding of developmental cardiovascular processes and potentiate progress of safe autologous regenerative therapies in pathological conditions. In this review, we summarize the latest trends on differentiation protocols of hiPSC-derived VSMCs and their potential application in vascular research and regenerative therapy. |
| Databáze: | OpenAIRE |
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