Connexins in melanoma: Potential role of Cx46 in its aggressiveness
| Autor: | Mauricio A. Retamal, Andrés Tittarelli, Viviana P. Orellana |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell signaling Cell Communication Dermatology Connexins General Biochemistry Genetics and Molecular Biology Metastasis 03 medical and health sciences 0302 clinical medicine Lens Crystalline medicine Humans Melanoma business.industry Cancer Extracellular vesicle medicine.disease Neoplasm Proteins Biomarker 030104 developmental biology Oncology 030220 oncology & carcinogenesis Second messenger system Cancer research Skin cancer business |
| Zdroj: | Pigment Cell & Melanoma Research. 34:853-868 |
| ISSN: | 1755-148X 1755-1471 |
| Popis: | Melanoma is the most aggressive skin cancer, and in metastatic advanced states, it is completely refractory to chemotherapy. Therefore, it is relevant to understand the molecular bases that rule their aggressiveness. Connexins (Cxs) are proteins that under normal physiological conditions participate in intercellular communication, via the exchange of signaling molecules between the cytoplasm and extracellular milieu and the exchange of ions/second messengers between the cytoplasm of contacting cells. These proteins have shown important roles in cancer progression, chemo- and radiotherapy resistance, and metastasis. Accordingly, Cx26 and Cx43 seem to play important roles in melanoma progression and metastasis. On the other hand, Cx46 is typically expressed in the eye lens, where it seems to be associated with oxidative stress protection in fiber lens cells. However, in the last decade, Cx46 expression has been associated with breast and brain cancers, due to its role in potentiation of both extracellular vesicle release and cancer stem cell-like properties. In this review, we analyzed a potential role of Cx46 as a new biomarker and therapeutic target in melanoma. |
| Databáze: | OpenAIRE |
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