Inflammatory signaling mechanisms in bipolar disorder
Autor: | Rodrigo Machado-Vieira, Courtney M Vecera, Gregory H Jones, Omar F. Pinjari |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Bipolar Disorder Endocrinology Diabetes and Metabolism Clinical Biochemistry Population Inflammation Review Disease Mitochondrion Mice 03 medical and health sciences 0302 clinical medicine NLRP3 Animals Humans Medicine Pharmacology (medical) Bipolar disorder education Molecular Biology Purine education.field_of_study business.industry Biochemistry (medical) Purinergic receptor Glutamate receptor Cell Biology General Medicine medicine.disease Mitochondria 030104 developmental biology BDNF Bipolar Glutamate medicine.symptom business Neuroscience P2X7 030217 neurology & neurosurgery Signal Transduction Hormone |
Zdroj: | Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-22 (2021) Journal of Biomedical Science |
ISSN: | 1423-0127 |
Popis: | Bipolar disorder is a decidedly heterogeneous and multifactorial disease, with a high individual and societal burden. While not all patients display overt markers of elevated inflammation, significant evidence suggests that aberrant immune signaling contributes to all stages of the disease, and likely explains the elevated rates of comorbid inflammatory illnesses seen in this population. While individual systems have been intensely studied and targeted, a relative paucity of attention has been given to the interconnecting role of inflammatory signals therein. This review presents an updated overview of some of the most prominent pathophysiologic mechanisms in bipolar disorder, from mitochondrial, endoplasmic reticular, and calcium homeostasis, to purinergic, kynurenic, and hormonal/neurotransmitter signaling, showing inflammation to act as a powerful nexus between these systems. Several areas with a high degree of mechanistic convergence within this paradigm are highlighted to present promising future targets for therapeutic development and screening. |
Databáze: | OpenAIRE |
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