Vulvar squamous carcinoma: prognostic role of DNA content
| Autor: | M. Pozzi, Laura Conti, V. Francavilla, L. De Franceschi, Giuseppe Maria Gandolfo, Giuseppe Atlante, Luciano Mariani, Atlante M, F. Sciarretta, M. Vercillo, R. Sindico, S. Rossi |
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| Rok vydání: | 1998 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Pathology Population Internal medicine medicine Carcinoma Humans education Vulvar Diseases Aged Neoplasm Staging Retrospective Studies Vulvar neoplasm Aged 80 and over education.field_of_study Ploidies Vulvar Neoplasms business.industry Obstetrics and Gynecology DNA Neoplasm Vulvar cancer Middle Aged medicine.disease Flow Cytometry Prognosis Squamous carcinoma Epidermoid carcinoma Lymphatic Metastasis Carcinoma Squamous Cell Female Vulvar Carcinoma business |
| Zdroj: | Gynecologic oncology. 71(2) |
| ISSN: | 0090-8258 |
| Popis: | DNA nuclear content was evaluated on 46 paraffin-embedded blocks of vulvar cancer by means of flow cytometry. Fifteen of 44 evaluable samples (34%) were found to have an aneuploid DNA pattern. Aneuplody showed a statistically significant relationship with tumor grading (P = 0.0004) and defined a subset of patients who have pathological characteristics of high risk, such as advanced stage of disease, deepest stromal invasion, or positive inguinal nodes. However, when a multivariate regression model was used, ploidy status did not have any prognostic role, while FIGO staging system was confirmed to be the strongest independent prognostic factor (P = 0.009). The integration of a panel of cell kinetic parameters with traditional features is worth investigating on a larger population. |
| Databáze: | OpenAIRE |
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