Role of thromboxane A2 in bradykinin-induced human isolated small bronchi contraction
| Autor: | Corinne A.E. Martin, Albert Hirsch, Charles Advenier, Emmanuel Naline, Mathieu Molimard |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Ruthenium red Muscle Relaxation Indomethacin Receptors Thromboxane Bradykinin Bronchi Thromboxane A2 chemistry.chemical_compound Internal medicine medicine Humans Vasoconstrictor Agents Dazoxiben Bradykinin receptor Receptor Aged Pharmacology Dose-Response Relationship Drug Biphenyl Compounds Imidazoles Muscle Smooth Middle Aged Ruthenium Red Prostaglandin Endoperoxides Synthetic Endocrinology chemistry Heptanoic Acids Capsaicin 15-Hydroxy-11 alpha 9 alpha-(epoxymethano)prosta-5 13-dienoic Acid Thromboxane-A Synthase Tachykinin receptor Muscle Contraction |
| Zdroj: | European Journal of Pharmacology. 278:49-54 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(95)00103-r |
| Popis: | We previously demonstrated that the bradykinin-induced contraction of human isolated small bronchi is inhibited by indomethacin, capsaicin (N-methyl-N-6-nonenamide) and ruthenium red but not by tachykinin receptor antagonists. The thromboxane A2 receptor (TP receptor) antagonist GR32191 ((1R-(1 alpha(Z),2 beta,3 beta,5 alpha))-(+)-7-(5-(((1,1'-biphenyl)-4-yl)- methoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl)-4-heptenoic acid, hydrochloride) (10(-10) to 10(-8) M) dose dependently inhibited the effect of bradykinin, suggesting the mediation of the TP receptor in the action of bradykinin. With higher concentrations of GR32191 (10(-7) and 10(-6) M) bradykinin induced a relaxation which was inhibited by indomethacin and by the bradykinin B2 receptor antagonist Hoe 140 (D-Arg0[Hyp3,Thi-5,D-Tic7,Oic8]bradykinin). The thromboxane A2 synthase inhibitor dazoxiben (4-(-2-(1H-imidazol-1-yl)ethoxy) benzoic acid hydrochloride) 10(-6) M inhibited the bradykinin-induced contraction, suggesting that thromboxane A2 was involved in TP receptor stimulation. The thromboxane A2 mimetic U-46619 (9,11-dideoxy-11 alpha,9 alpha-epoxy-methano-prostaglandin F2 alpha)-induced contraction of human distal bronchi was not inhibited by capsaicin and ruthenium red. Our data suggest that bradykinin contracts human isolated small bronchi through thromboxane A2 release. The inhibitory effect of ruthenium red and capsaicin on the bradykinin response may be due to inhibition of thromboxane A2 release or arachidonic mobilisation. |
| Databáze: | OpenAIRE |
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