Significant Difference of Immune Cell Fractions and Their Correlations With Differential Expression Genes in Parkinson's Disease
| Autor: | Fei Ling, Jiaqi Hu, Yilin Huang, Chongyin Han, Yuhu Zhang, Wei Luo, Huisheng Liu, Zhenggang Zhong |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aging
Cell type Parkinson's disease Cognitive Neuroscience Central nervous system Neurosciences. Biological psychiatry. Neuropsychiatry Substantia nigra Tregs Mitochondrion Biology medicine.disease Pathogenesis Immune system medicine.anatomical_structure immune cells substantia nigra blood Immunology medicine Parkinson’s disease PIDD1 RC321-571 Death domain Neuroscience Original Research |
| Zdroj: | Frontiers in Aging Neuroscience Frontiers in Aging Neuroscience, Vol 13 (2021) |
| ISSN: | 1663-4365 |
| Popis: | Parkinson’s disease (PD) is the second most neurodegenerative disease in the world. T cell infiltration in the central nervous system (CNS) has provided insights that the peripheral immune cells participate in the pathogenesis of PD. However, the association between the peripheral immune system and CNS remains to be elucidated. In this study, we analyzed incorporative substantia nigra (SN) expression data and blood expression data using the CIBERSORT to obtain the 22 immune cell fractions and then explored the molecular function to identify the potential key immune cell types and genes of PD. We observed that the proportions of naïve CD4 T cells, gamma delta T cells, resting natural killer (NK) cells, neutrophils in the blood, and regulatory T cells (Tregs) in the SN were significantly different between patients with PD and healthy controls (HCs). We identified p53-induced death domain protein 1 (PIDD1) as the hub gene of a PD-related module. The enrichment score of the neuron-specific gene set was significantly different between PD and HC, and genes in the neuron-related module were enriched in the biological process about mitochondria and synapses. These results suggested that the fractions of naïve CD4 T cells, gamma delta T cells, resting NK cells, and neutrophils may be used as a combined diagnostic marker in the blood, and Tregs in SN may be a potential therapeutic design target for PD. |
| Databáze: | OpenAIRE |
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