Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

Autor:	Stephen E. Webber, Maria V. Sergeeva, Amit M. Shah, Rupal Patel, Frank Ruebsam, Leo Kirkovsky, Darian M. Bartkowski, Charles R. Kissinger, Benjamin K. Ayida, Thomas G. Nolan, Ruhi Kamran, Richard E. Showalter, Daniel A. Norris, Mei Tsan, Zhongxiang Sun, Laurie A. LeBrun, Qiang Zhao, Yuefen Zhou
Rok vydání:	2008
Předmět:	Stereochemistry Hepatitis C virus Clinical Biochemistry Pharmaceutical Science Hepacivirus Viral Nonstructural Proteins medicine.disease_cause Crystallography X-Ray Biochemistry Chemical synthesis Antiviral Agents Structure-Activity Relationship Drug Discovery medicine Structure–activity relationship Combinatorial Chemistry Techniques Humans Replicon Molecular Biology chemistry.chemical_classification Bicyclic molecule biology Molecular Structure Chemistry Organic Chemistry Pyridazines Enzyme Enzyme inhibitor Drug Design Microsome biology.protein Microsomes Liver Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry letters. 18(18)
ISSN:	1464-3405
Popis:	Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Among these, compound 4c displayed potent inhibitory activities in biochemical and replicon assays (IC(50) (1b)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b2df2c4fe90fa8fcfab7f11ff7ddff https://pubmed.ncbi.nlm.nih.gov/18722768 Zobrazit plný text záznamu Full Text from ScienceDirect