Relationship between plasma osteocalcin, glycaemic control and components of metabolic syndrome in adult Nigerians with type 2 diabetes mellitus
| Autor: | E U Egbuagha, Elaine Azinge, Henry Chima Okpara, Chinelo P Onyenekwu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteocalcin 030209 endocrinology & metabolism Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Risk Factors Internal medicine Diabetes mellitus Internal Medicine medicine Humans Obesity Aged Metabolic Syndrome biology Triglyceride business.industry Nigerians Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease 030104 developmental biology Endocrinology Cross-Sectional Studies chemistry Diabetes Mellitus Type 2 biology.protein Female Metabolic syndrome business Body mass index |
| Popis: | AIMS: To determine the levels of plasma osteocalcin (OC) in Nigerians with type 2 diabetes mellitus (DM) and compare these to levels in non-diabetic controls (NDM). To assess the relationship of OC to glycaemic control and parameters of metabolic syndrome (MetS) and compare its levels in Nigerians with and without MetS. METHODS: The waist circumference (WC), body mass index (BMI) and blood pressure of 200 study participants were taken. Plasma osteocalcin, fasting glucose (FPG), glycated haemoglobin (HbA1c), high density lipoprotein cholesterol (HDL-c) and triglyceride (TG) levels were determined. Metabolic syndrome was defined by the International Diabetes Federation criteria. Statistical significance was set at 0.05. RESULTS: Osteocalcin levels were lower in the DM group (p = 0.002) and inversely related to FPG (r = −0.198, p = 0.003), HbA1c (r = −0.313, p |
| Databáze: | OpenAIRE |
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