A novel restorative pulmonary valved conduit in a chronic sheep model: Mid-term hemodynamic function and histologic assessment
| Autor: | Ger B.W.E. Bennink, Martijn Cox, Renu Virmani, Elena Ladich, Marieke Brugmans, Thierry Carrel, Sho Torii, Oleg Svanidze |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Aortic root Hemodynamics 030204 cardiovascular system & hematology Prosthesis Design Valved conduit 03 medical and health sciences Postoperative Complications 0302 clinical medicine Internal medicine medicine.artery medicine Animals Degradation process 610 Medicine & health Bioprosthesis Heart Valve Prosthesis Implantation Pulmonary Valve Sheep business.industry Calcinosis medicine.disease Disease Models Animal medicine.anatomical_structure 030228 respiratory system Echocardiography Heart Valve Prosthesis Pulmonary valve Pulmonary artery Cardiology Surgery Thickening Cardiology and Cardiovascular Medicine business Calcification |
| DOI: | 10.7892/boris.124627 |
| Popis: | Objective To evaluate the safety and the short-term function of a novel pulmonary valved conduit (Xeltis Pulmonary Valved Conduit; XPV) up to 12 months in a sheep model. Methods XPV and Hancock bioprosthetic valved conduits (H, used as control) were implanted in adult sheep in the pulmonary artery position. Animals were killed at 2 months (n = 6 XPV), 6 months (n = 6 XPV and n = 3 H), and 12 months (n = 6 XPV) and examined histologically. During follow-up, function of the device as well as diameter of both XPV and H were assessed by transthoracic echocardiography. Results Of 18 animals that received an XPV, 15 survived until they were killed; 3 animals that received H survived the planned observational interval. XPV showed mild neointimal thickening and degradation beginning at 2 months with an ongoing process until 12 months. Only 1 of the 18 animals with XPV had significant calcification at 6 months. Pathologic specimen did not show any significant narrowing of the conduit whereas neointimal thickness showed a peak at 6 months. Inflammatory process reached a maximum at 6 months and the degradation process at 12 months. Gel permeation chromatography analysis showed molecular weight loss beginning at 2 months with a peak at 12 months for the conduit with slower absorption for the leaflets. The wall of the H conduits showed more neointimal thickening, narrowing, and calcification compared with XPV, but the leaflets demonstrated minimal changes. Conclusions Both conduits demonstrated an acceptable safety and functionality. Significant calcification was rarely observed in the XPV, whereas the H developed more neointimal thickness with calcification of the porcine aortic root portion of the wall. |
| Databáze: | OpenAIRE |
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