New oral anticoagulants: will they replace warfarin?
| Autor: | James W. Little |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
medicine.drug_mechanism_of_action Morpholines Factor Xa Inhibitor Administration Oral Hemorrhage Thiophenes Pathology and Forensic Medicine Dabigatran Drug Hypersensitivity Thrombin Rivaroxaban Thromboembolism medicine Humans Drug Interactions Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Intensive care medicine Stroke Clotting factor business.industry Warfarin Anticoagulants medicine.disease Liver Direct thrombin inhibitor Gastritis Anesthesia beta-Alanine Benzimidazoles Surgery Oral Surgery business Factor Xa Inhibitors medicine.drug |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 113:575-580 |
| ISSN: | 2212-4403 |
| DOI: | 10.1016/j.oooo.2011.10.006 |
| Popis: | Vitamin K antagonists, such as warfarin, are considered to be the treatment of choice to prevent thromboembolic events, but problems, such as the need for frequent dose adjustment and monitoring of coagulation status, as well as multiple drug and food interactions, make their use difficult for both physician and patient. Two new anticoagulants are now being considered as possible replacements of vitamin K antagonists. Dabigatran, an oral direct thrombin inhibitor has already been approved in the USA for prevention of stroke in patients with atrial fibrillation. Rivaroxaban, a factor Xa inhibitor, and dabigatran are licensed in Europe and Canada for short-term thromboprophylaxis after elective hip or knee replacement surgery. The advantages of these drugs are that they are safe and effective, require no monitoring, have a direct mode of action against only one clotting factor (thrombin or factor Xa), have limited drug interactions, and have rapid peak blood levels. Based on the fact that dabigatran has already been approved for use in the USA, it would appear that it has an advantage over rivaroxaban in becoming the replacement drug for vitamin K antagonists. |
| Databáze: | OpenAIRE |
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