Novel insights into the regulation of cellular catabolic metabolism in macrophages through nuclear receptors
| Autor: | Ulrich Stifel, Giorgio Caratti, Jan Tuckermann |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
immunometabolism
Kernrezeptor Biophysics nuclear receptors PPAR Biochemistry Receptors Glucocorticoid DDC 570 / Life sciences Structural Biology ddc:570 Immunologie Genetics Humans ddc:610 Molecular Biology Liver X Receptors VDR Inflammation Stoffwechsel Katabolismus Macrophages Entzündung Cell Biology Orphan Nuclear Receptors GR Receptors Cytoplasmic and nuclear Makrophage Peroxisome Proliferators LXR Immune system Metabolism DDC 610 / Medicine & health cellular metabolism |
| Zdroj: | FEBS Letters. 596:2617-2629 |
| ISSN: | 1873-3468 0014-5793 |
| Popis: | Regulation of cellular catabolic metabolism in immune cells has recently become a major concept for resolution of inflammation. Nuclear receptors (NRs), including peroxisome proliferator activator receptors, 1,25-dihydroxyvitamin D (3) receptor, liver X receptors, glucocorticoid receptors, oestrogen-related receptor α and nuclear receptor 4A1, have been identified as major modulators of inflammation, affecting innate immune cells, such as macrophages. Evidence emerges on how NRs regulate cellular metabolism in macrophages during inflammatory processes and contribute to the resolution of inflammation. This could have new implications for our understanding of how NRs shape immune responses and inform anti-inflammatory drug design. This review will highlight the recent developments about NRs and their role in cellular metabolism in macrophages. publishedVersion |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text