The nested variant of urothelial carcinoma: an aggressive tumor closely simulating benign lesions
| Autor: | Emine Dündar, Mustafa Fuat Acikalin, Cavit Can |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Urologic Neoplasms Obturator Lymph Node Pathology and Forensic Medicine Muscular layer Diagnosis Differential Prostatic urethra Neoplasms Medicine Humans Neoplasm Invasiveness Perivesicular Urothelial carcinoma Aged business.industry Soft tissue General Medicine Middle Aged Vesicula seminalis Carcinoma Papillary Gene Expression Regulation Neoplastic medicine.anatomical_structure Ki-67 Antigen Oncology Immunohistochemistry Neoplasm Recurrence Local Tumor Suppressor Protein p53 business |
| Zdroj: | Pathology oncology research : POR. 12(2) |
| ISSN: | 1219-4956 |
| Popis: | The “nested” variant is a rare form of urothelial carcinoma and its biologic behavior is highly aggressive. Herein two new cases of nested variant of urothelial carcinoma with immunohistochemical examination are presented. In one of the cases, the tumor extended through the bladder wall into the perivesicular soft tissue, prostatic urethra and left vesicula seminalis, and metastasized to obturator lymph nodes. In the other case, invasion of muscular layer was observed and three recurrences were developed during a followup period of 23 months. Both tumors of our study demonstrated high p53 and Ki-67 indices, supporting the aggressive nature of such tumors.(Pathology Oncology Research Vol 12, No 2, 105–107) |
| Databáze: | OpenAIRE |
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