Hyperglycemia during acute myocardial infarction in patients who are treated by primary percutaneous coronary intervention: Impact on long-term prognosis
| Autor: | Michael Kapeliovich, Ariel Roguin, Shlomo Amikam, Monther Boulos, Ehud Grenadier, Rafael Beyar, Luis Gruberg, Shahar Lavi, Walter Markiewicz, Haim Hammerman |
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| Rok vydání: | 2008 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Time Factors Percutaneous medicine.medical_treatment Myocardial Infarction Internal medicine Angioplasty medicine Humans In patient Prospective Studies Myocardial infarction Angioplasty Balloon Coronary Target lesion revascularization business.industry Percutaneous coronary intervention Middle Aged Prognosis medicine.disease Hyperglycemia Circulatory system Cardiology Female Risk of death Cardiology and Cardiovascular Medicine business |
| Zdroj: | International Journal of Cardiology. 123:117-122 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2006.11.222 |
| Popis: | Transient hyperglycemia is common during acute myocardial infarction in non-diabetic patients and is associated with a worse outcome. There is limited data on the outcome of patients who undergo primary percutaneous coronary intervention and have transient hyperglycemia.Fasting plasma glucose was measured in 431 consecutive acute myocardial infarction patients who underwent primary percutaneous coronary interventions. Patients were classified into three groups: non-diabetics/non-hyperglycemic (NDNH, glucose126 mg/dL; n=224); non-diabetics/hyperglycemic (NDH, glucoseor = 126 mg/dL; n=119); and diabetics (n=88). Data were analyzed according to the different groups and according to exact glucose levels.In-hospital mortality was significantly lower in NDNH (1%) compared to NDH (8%) and diabetic (5%) patients (p=0.01). One-year cumulative mortality was highest (10%) in patients with NDH (p0.001). One year target lesion revascularization rates were identical in NDNH and NDH patients (6% vs. 8%) and higher in diabetic patients (19%, p=0.001). In a multivariate model, a striking increase in the risk of death (0.6%, p=0.05) and target lesion revascularization (2%, p0.0001) was found for every increment of 1 mg/dL in glucose level.Transient hyperglycemia in non-diabetic acute myocardial infarction patients who undergo primary percutaneous coronary interventions is associated with high one-year mortality. One year target lesion revascularization rates were significantly higher in diabetics compared to non-diabetics with normoglycemia or transient hyperglycemia. |
| Databáze: | OpenAIRE |
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