Chest radiographic and CT findings in hyperleukocytic acute myeloid leukemia
| Autor: | Michael Stefanski, Andry Van de Louw, Carlos Jamis-Dow, David F. Claxton, Ruchi J Desai, Michael G. Bayerl |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Myeloid Pleural effusion Radiography Observational Study acute myeloid leukemia Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine White blood cell Leukocytes medicine Humans Aged Retrospective Studies chest radiograph Aged 80 and over acute respiratory failure business.industry leukostasis computed tomography Leukostasis Retrospective cohort study General Medicine Middle Aged medicine.disease Pulmonary embolism Leukemia Myeloid Acute Leukemia medicine.anatomical_structure 030220 oncology & carcinogenesis Female Radiography Thoracic Radiology Tomography X-Ray Computed business Research Article 030215 immunology |
| Zdroj: | Medicine |
| ISSN: | 0025-7974 |
| DOI: | 10.1097/md.0000000000005285 |
| Popis: | Hyperleukocytic acute myeloid leukemia (AML) is associated with pulmonary complications and high early mortality rate, but given its rarity, data on chest radiographic presentation are scarce. We retrospectively reviewed the charts of 73 AML patients admitted with white blood cell count >100 × 109/L between 2003 and 2014 in order to describe the chest radiographic and computed tomography (CT) findings and to correlate them with AML subtype and respiratory symptoms. Forty-two of the 73 patients (58%) overall and 36 of the 54 patients (67%) with clinical signs of pulmonary leukostasis had abnormal radiographs on admission. The presence of radiographic abnormalities was significantly associated with dyspnea and oxygen/ventilatory support requirements (P |
| Databáze: | OpenAIRE |
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