Treatment of acute Nipah encephalitis with ribavirin
Autor: | Sai Kit Lam, Adeeba Kamarulzaman, Tarmizi Thayaparan, Sree Raman Kunjapan, Heng‐Thay Chong, K B Chua, Nee‐Kong Chew, Khean Jin Goh, Chong Tin Tan |
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Rok vydání: | 2001 |
Předmět: |
Adult
Male China Pediatrics medicine.medical_specialty Side effect viruses medicine.medical_treatment Treatment Refusal chemistry.chemical_compound Asian People Ribavirin medicine Humans Encephalitis Viral Retrospective Studies Chemotherapy biology business.industry Malaysia virus diseases Outbreak Retrospective cohort study biochemical phenomena metabolism and nutrition biology.organism_classification medicine.disease Virology digestive system diseases Treatment Outcome Neurology chemistry Paramyxovirinae Female Neurology (clinical) Viral disease business Encephalitis Henipavirus |
Zdroj: | Annals of Neurology. 49:810-813 |
ISSN: | 1531-8249 0364-5134 |
DOI: | 10.1002/ana.1062 |
Popis: | Nipah virus, a newly identified paramyxovirus caused a severe outbreak of encephalitis in Malaysia with high fatalities. We report an open-label trial of ribavirin in 140 patients, with 54 patients who were managed prior to the availability of ribavirin or refused treatment as control. There were 45 deaths (32%) in the ribavirin arm; 29 deaths (54%) occurred in the control arm. This represents a 36% reduction in mortality (p = 0.011). There was no associated serious side effect. This study suggests that ribavirin is able to reduce the mortality of acute Nipah encephalitis. |
Databáze: | OpenAIRE |
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