Treatment of acute Nipah encephalitis with ribavirin

Autor: Sai Kit Lam, Adeeba Kamarulzaman, Tarmizi Thayaparan, Sree Raman Kunjapan, Heng‐Thay Chong, K B Chua, Nee‐Kong Chew, Khean Jin Goh, Chong Tin Tan
Rok vydání: 2001
Předmět:
Zdroj: Annals of Neurology. 49:810-813
ISSN: 1531-8249
0364-5134
DOI: 10.1002/ana.1062
Popis: Nipah virus, a newly identified paramyxovirus caused a severe outbreak of encephalitis in Malaysia with high fatalities. We report an open-label trial of ribavirin in 140 patients, with 54 patients who were managed prior to the availability of ribavirin or refused treatment as control. There were 45 deaths (32%) in the ribavirin arm; 29 deaths (54%) occurred in the control arm. This represents a 36% reduction in mortality (p = 0.011). There was no associated serious side effect. This study suggests that ribavirin is able to reduce the mortality of acute Nipah encephalitis.
Databáze: OpenAIRE