Association of deficits in short-term learning and Aβ and hippocampal volume in cognitively normal adults
| Autor: | Jurgen Fripp, Loren Bruns, Paul Maruff, Yen Ying Lim, Andrea Mills, Colin L. Masters, Christopher Fowler, Jenalle E. Baker, Stephanie R. Rainey-Smith, David Ames |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Neuroimaging Hippocampal formation Audiology Hippocampus 050105 experimental psychology Cerebral Ventricles 03 medical and health sciences 0302 clinical medicine Medicine Hippocampus (mythology) Humans 0501 psychology and cognitive sciences Cognitive Dysfunction Association (psychology) Aged Amyloid beta-Peptides medicine.diagnostic_test business.industry Learning Disabilities 05 social sciences Magnetic resonance imaging Cognition Magnetic Resonance Imaging Confidence interval Healthy Volunteers Positron-Emission Tomography Hippocampal volume Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Neurology. 95(18) |
| ISSN: | 1526-632X |
| Popis: | ObjectiveTo determine the extent to which deficits in learning over 6 days are associated with β-amyloid–positive (Aβ+) and hippocampal volume in cognitively normal (CN) adults.MethodsEighty CN older adults who had undergone PET neuroimaging to determine Aβ status (n = 42 Aβ− and 38 Aβ+), MRI to determine hippocampal and ventricular volume, and repeated assessment of memory were recruited from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Participants completed the Online Repeatable Cognitive Assessment–Language Learning Test (ORCA-LLT), which required they learn associations between 50 Chinese characters and their English language equivalents over 6 days. ORCA-LLT assessments were supervised on the first day and were completed remotely online for all remaining days.ResultsLearning curves in the Aβ+ CN participants were significantly worse than those in matched Aβ− CN participants, with the magnitude of this difference very large (d [95% confidence interval (CI)] 2.22 [1.64–2.75], p < 0.001), and greater than differences between these groups for memory decline since their enrollment in AIBL (d [95% CI] 0.52 [0.07–0.96], p = 0.021), or memory impairment at their most recent visit. In Aβ+ CN adults, slower rates of learning were associated with smaller hippocampal and larger ventricular volumes.ConclusionsThese results suggest that in CN participants, Aβ+ is associated more strongly with a deficit in learning than any aspect of memory dysfunction. Slower rates of learning in Aβ+ CN participants were associated with hippocampal volume loss. Considered together, these data suggest that the primary cognitive consequence of Aβ+ is a failure to benefit from experience when exposed to novel stimuli, even over very short periods. |
| Databáze: | OpenAIRE |
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