| Autor: |
Lahari Basu, Vriti Bhagat, Ma Enrica Angela Ching, Anna Di Giandomenico, Sylvie Dostie, Dana Greenberg, Marley Greenberg, Jiwon Hahm, N. Zoe Hilton, Krista Lamb, Emelien M. Jentz, Matt Larsen, Cassandra A.A. Locatelli, MaryAnn Maloney, Christine MacGibbon, Farida Mersali, Christina Marie Mulchandani, Adhiyat Najam, Ishnoor Singh, Tom Weisz, Jordan Wong, Peter A. Senior, Jennifer L. Estall, Erin E. Mulvihill, Robert A. Screaton |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Canadian journal of diabetes. |
| ISSN: |
2352-3840 |
| Popis: |
Navigating the coronavirus disease-2019 (COVID-19, now COVID) pandemic has required resilience and creativity worldwide. Despite early challenges to productivity, more than 2,000 peer-reviewed articles on islet biology were published in 2021. Herein we highlight noteworthy advances in islet research between January 2021 and April 2022, focussing on 5 areas. First, we discuss new insights into the role of glucokinase, mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase and mitochondrial function on insulin secretion from the pancreatic ß cell, provided by new genetically modified mouse models and live imaging. We then discuss a new connection between lipid handling and improved insulin secretion in the context of glucotoxicity, focussing on fatty acid-binding protein 4 and fetuin-A. Advances in high-throughput "omic" analysis evolved to where one can generate more finely tuned genetic and molecular profiles within broad classifications of type 1 diabetes and type 2 diabetes. Next, we highlight breakthroughs in diabetes treatment using stem-cell-derived ß cells and innovative strategies to improve islet survival posttransplantation. Last, we update our understanding of the impact of severe acute respiratory syndrome-coronavirus-2 infection on pancreatic islet function and discuss current evidence regarding proposed links between COVID and new-onset diabetes. We address these breakthroughs in 2 settings: one for a scientific audience and the other for the public, particularly those living with or affected by diabetes. Bridging biomedical research in diabetes to the community living with or affected by diabetes, our partners living with type 1 diabetes or type 2 diabetes also provide their perspectives on these latest advances in islet biology. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect