Influence of hyperuricemia treatment on postoperative acute kidney injury among hyperuricemia patients: a single-center retrospective database analysis
| Autor: | Tatsuki Matsumoto, Shinichiro Watanabe, Taro Horino, Fabricio M. Locatelli, Takashi Kawano, Keitaro Nagata, Masataka Yokoyama, Yutaka Hatakeyama, Yoshiyasu Okuhara, Yoshio Terada |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Allopurinol 030232 urology & nephrology lcsh:Medicine Hyperuricemia Kidney Single Center Gastroenterology General Biochemistry Genetics and Molecular Biology Retrospective database 03 medical and health sciences chemistry.chemical_compound Postoperative Complications 0302 clinical medicine Risk Factors Internal medicine medicine Humans Postoperative Period 030212 general & internal medicine lcsh:Science (General) lcsh:QH301-705.5 Aged Retrospective Studies Creatinine business.industry Incidence Prevention Incidence (epidemiology) lcsh:R Acute kidney injury General Medicine Acute Kidney Injury Middle Aged medicine.disease Uric Acid Research Note lcsh:Biology (General) chemistry Uric acid Female business lcsh:Q1-390 Glomerular Filtration Rate medicine.drug |
| Zdroj: | BMC Research Notes BMC Research Notes, Vol 12, Iss 1, Pp 1-5 (2019) |
| ISSN: | 1756-0500 |
| Popis: | ObjectiveHyperuricemia has been reported to be associated with the development of postoperative acute kidney injury (pAKI). However, it remains underdetermined whether hyperuricemia treatment could decrease the potential risk of pAKI. Here, we investigated this hypothesis among hyperuricemia patients with previously normal renal function by performing a retrospective database analysis.ResultsThe study screened 18,169 patients, and were examined preoperative serum creatinine, uric acid, and postoperative serum creatinine. Eight hundred thirty-six patients were finally analyzed for the study, of whom 232 were in the treatment group and 604 were in the non-treatment control group. After adjustment for multi-covariates including baseline (pre-treatment) serum uric acid (SUA) levels, the incidence of pAKI in the treatment group (9.05%; 95% CI 6.04–12.1%) was significantly lower than that in the control group (14.2%; 95% CI 11.2–17.2%). On the other hand, further adjusting for preoperative SUA levels, there was no significant difference in the expected incidence of pAKI between the groups. |
| Databáze: | OpenAIRE |
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