Inflammatory Bowel Disease Increases the Risk of Venous Thromboembolism in Children: A Population-Based Matched Cohort Study

Autor:	Yunsong Cui, Harminder Singh, David R. Mack, Laura E Targownik, Divine Tanyingoh, Lisa M. Lix, Anne M. Griffiths, Jeffrey D. McCurdy, Stephen G Fung, Kevan Jacobson, Wael El-Matary, Stephanie Coward, Anthony R. Otley, Sarah Spruin, Christopher Filliter, Shabnaz Siddiq, Therese A. Stukel, M Ellen Kuenzig, Trevor J.B. Dummer, Zoann Nugent, Jennifer Jones, Matthew W Carroll, Gilaad G. Kaplan, Alain Bitton, Geoffrey C. Nguyen, Sanjay K. Murthy, Juan Nicolás Peña-Sánchez, Charles N. Bernstein, Eric I Benchimol
Rok vydání:	2021
Předmět:	Male Canada medicine.medical_specialty complications Databases Factual Population Inflammatory bowel disease paediatrics Cohort Studies 03 medical and health sciences 0302 clinical medicine inflammatory bowel disease Risk Factors Internal medicine medicine Humans Child education AcademicSubjects/MED00260 education.field_of_study routinely collected health data Proportional hazards model business.industry Incidence Incidence (epidemiology) Hazard ratio Child Health Gastroenterology Absolute risk reduction Original Articles Venous Thromboembolism General Medicine Inflammatory Bowel Diseases medicine.disease Confidence interval 3. Good health Pulmonary embolism 030220 oncology & carcinogenesis health administrative data epidemiology Female 030211 gastroenterology & hepatology business
Zdroj:	Journal of Crohn's & Colitis
ISSN:	1876-4479 1873-9946
Popis:	Background and Aims Although venous thromboembolism [VTE] is a well-known complication of inflammatory bowel disease [IBD] in adults, limited data exist on the risk in children. We report the incidence of VTE among children with and without IBD. Methods We conducted a matched cohort study within a distributed network of population-based Canadian provincial health administrative databases. Children Results The 5-year incidence of VTE among 3593 children with IBD was 31.2 [95% CI 23.7–41.0] per 10 000 person-years [PY] compared to 0.8 [95% CI 0.4–1.7] per 10 000 PY among 16 289 children without IBD [unadjusted IRR 38.84, 95% CI 16.59–90.83; adjusted HR 22.91, 95% CI 11.50–45.63]. VTE was less common in Crohn’s disease than ulcerative colitis [unadjusted IRR 0.47, 95% CI 0.27–0.83; adjusted HR 0.52, 95% CI 0.29–0.94]. The findings were similar for deep vein thrombosis and pulmonary embolism when comparing children with and without IBD. Conclusions The risk of VTE is much higher in children with IBD than controls without IBD. While the absolute risk is low, we found a higher incidence rate than previously described in the pediatric literature. Conference Presentation: An abstract based on the data included in this paper was presented at Canadian Digestive Diseases Week [Montréal, Canada] in March 2020.
Databáze:	OpenAIRE
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