Serum levels of coenzyme Q in patients with Lewy body disease
| Autor: | F. de Bustos, S. Ortiz, Julián Benito-León, S. Pérez, Jorge Manzanares, JoséAntonio Molina, T. del Ser, J.M. Oliva, M. Seijo |
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| Rok vydání: | 2002 |
| Předmět: |
Lewy Body Disease
Male medicine.medical_specialty Neurology Ubiquinone Coenzymes Synucleins Down-Regulation Apoptosis Cytochrome c Group Nerve Tissue Proteins Neuropsychological Tests Body Mass Index chemistry.chemical_compound Degenerative disease Internal medicine medicine Humans Age of Onset Biological Psychiatry Aged Coenzyme Q10 Mini–Mental State Examination medicine.diagnostic_test Cholesterol business.industry Age Factors medicine.disease Oxidative Stress Psychiatry and Mental health Endocrinology chemistry Coenzyme Q – cytochrome c reductase Female Neurology (clinical) Age of onset business Body mass index hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Neural Transmission. 109:1195-1201 |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/s00702-001-0761-5 |
| Popis: | The purpose of the present study was to compare serum levels of coenzyme Q(10) (CoQ(10)) and the coenzyme Q(10) cholesterol (CoQ(10)/cholesterol) ratio in 18 patients with Lewy body disease (LBD) with 20 matched controls. The mean serum coenzyme Q10 levels in patients with LBD were significantly reduced with respect to control group, however, no differences were found in CoQ(10)/cholesterol ratio between LBD patients and control group. There was no correlation among CoQ(10) and CoQ(10)/cholesterol ratio with age, age of onset, body mass index, duration of the disease or scores of the Mini Mental State Examination, UPDRS and Hoehn and Yahr stage. These results suggest the involvement of this enzimatic system in the pathogenic mechanism of LBD. |
| Databáze: | OpenAIRE |
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