A Retrospective Study on Mycophenolic Acid Drug Interactions: Effect of Prednisone, Sirolimus, and Tacrolimus With MPA
| Autor: | Ram N. Singh, Guido Filler, Ekaterina Kirilova Todorova, Ana Catalina Alvarez-Elías, Elisa C. Yoo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Graft Rejection
Male medicine.medical_specialty Urology 030230 surgery Mycophenolate 030226 pharmacology & pharmacy Pediatrics Mycophenolic acid Tacrolimus 03 medical and health sciences 0302 clinical medicine Prednisone Medicine Humans Pharmacology (medical) Drug Interactions Child Preschool Kidney transplantation Retrospective Studies Pharmacology Sirolimus medicine.diagnostic_test business.industry Mycophenolic Acid medicine.disease Kidney Transplantation Transplantation surgical procedures operative Therapeutic drug monitoring Area Under Curve Child Preschool Female Drug Monitoring business Immunosuppressive Agents medicine.drug Glomerular Filtration Rate |
| Zdroj: | Paediatrics Publications |
| Popis: | Mycophenolic acid (MPA), the active compound of mycophenolate mofetil (MMF), is widely used as an antirejection drug after renal transplantation. There is growing evidence supporting the notion that there is substantial variability in the intra- and interpatient exposure to MPA. Drug interactions involving MPA with tacrolimus, steroids, and sirolimus have been understudied. The objective of this study was to determine the relationship between MPA, steroids, tacrolimus, and sirolimus. MPA trough concentrations from 37 pediatric renal transplant recipients (mean age 7.6 years at transplant) followed for a median follow-up of 7.8 years were analyzed retrospectively and 2131 dose-normalized MPA trough concentrations were evaluated against all known covariates including all concomitant immunosuppressant drug doses and exposure, age, albumin, hematocrit, and estimated glomerular filtration rate (eGFR). Age, hematocrit, and estimated glomerular filtration rate affected the dose-normalized MPA trough concentrations. The authors used appropriate linear regression univariate models and created 5 different multivariate models to examine individual drug-drug interactions (DDIs). Although the authors' findings support the notion that there is a DDI between MMF and both sirolimus and steroids, the sample size was small, and these findings should be confirmed in future studies. The authors found no DDIs between tacrolimus and MMF, the prodrug of MPA. These findings are important because there is a tendency to under-dose MMF early and to overdose late after transplantation. The DDI between sirolimus and MMF has not been described. Although therapeutic drug monitoring of MMF therapy is often not performed, the data presented here indicate a necessity for therapeutic drug monitoring. This is especially true when converting from tacrolimus to sirolimus, as a way to avoid MPA underexposure and organ rejection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|