Blastocyst-endometrium interaction: intertwining a cytokine network
| Autor: | C Guzmán-Martinez, John Fredy Castro-Alvarez, Julio César Bueno-Sánchez, W A Castro-Rendón |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Vascular Endothelial Growth Factor A
medicine.medical_specialty Physiology Immunology Biophysics Embryonic Development Biology Endometrium Biochemistry Leukemia Inhibitory Factor Mice Epidermal growth factor Pregnancy Internal medicine medicine Animals Humans Decidual cells Blastocyst Embryo Implantation General Pharmacology Toxicology and Pharmaceutics Epidermal Growth Factor General Neuroscience Trophoblast Embryo Cell Differentiation Cell Biology General Medicine Embryo Transfer Embryo transfer Cell biology Trophoblasts medicine.anatomical_structure Endocrinology embryonic structures Intercellular Signaling Peptides and Proteins Female Leukemia inhibitory factor Heparin-binding EGF-like Growth Factor Interleukin-1 |
| Zdroj: | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 39(11) |
| ISSN: | 0100-879X |
| Popis: | The successful implantation of the blastocyst depends on adequate interactions between the embryo and the uterus. The development of the embryo begins with the fertilized ovum, a single totipotent cell which undergoes mitosis and gives rise to a multicellular structure named blastocyst. At the same time, increasing concentrations of ovarian steroid hormones initiate a complex signaling cascade that stimulates the differentiation of endometrial stromal cells to decidual cells, preparing the uterus to lodge the embryo. Studies in humans and in other mammals have shown that cytokines and growth factors are produced by the pre-implantation embryo and cells of the reproductive tract; however, the interactions between these factors that converge for successful implantation are not well understood. This review focuses on the actions of interleukin-1, leukemia inhibitory factor, epidermal growth factor, heparin-binding epidermal growth factor, and vascular endothelial growth factor, and on the network of their interactions leading to early embryo development, peri-implantatory endometrial changes, embryo implantation and trophoblast differentiation. We also propose therapeutical approaches based on current knowledge on cytokine interactions. |
| Databáze: | OpenAIRE |
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