Phase 1 of an in vitro neurotoxicological pre-validation trial
| Autor: | S.P. Williams, S. O'Hare, M.R. Cookson, C.K. Atterwill, Michael J. Garle, V.W. Pentreath, R. McClean, C. Egan, J. Davenport-Jones |
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| Rok vydání: | 1994 |
| Předmět: |
End point
Computer science Validation test business.industry education Frame (networking) General Medicine Toxicology Machine learning computer.software_genre Set (abstract data type) health services administration Artificial intelligence business computer health care economics and organizations Pre validation |
| Zdroj: | Toxicology in Vitro. 8:799-802 |
| ISSN: | 0887-2333 |
| DOI: | 10.1016/0887-2333(94)90071-x |
| Popis: | In the absence of a formal in vitro alternative model for neurotoxicity testing, the CellTox Centre, in collaboration with the University of Salford, FRAME and the EEC, has set up an initial pre-validation trial of a three-tiered scheme that was originally proposed in 1989. Using a cell battery of neuroblastomas and primary neural cultures (Tier I) and primary astrocytes (Tier III) an initial set of 20 chemicals (out of a reference set of 40 chemicals) has been assessed for neurotoxicity using a multiple end point assay system. The methods used were relatively simple, rapid and inexpensive, and the chemical end points were easily quantified. The results of the pre-validation trial have enabled us to revise the first tier of the proposed tiered system for full micro-validation. |
| Databáze: | OpenAIRE |
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