Composite Scores of Plasma Tau and β-Amyloids Correlate with Dementia in Down Syndrome
| Autor: | Ai Chu Huang, Ming-Jang Chiu, Lih Maan Chang, Yin-Hsiu Chien, Wei Quan Fang, Ni-Chung Lee, Jen Jie Chieh, Shieh Yueh Yang, Wuh-Liang Hwu |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Down syndrome Composite score Physiology Cognitive Neuroscience tau Proteins Positive correlation Logistic regression Biochemistry Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine Dementia Humans 030304 developmental biology 0303 health sciences Amyloid beta-Peptides business.industry Area under the curve Cell Biology General Medicine Middle Aged medicine.disease Biomarker (medicine) Female Down Syndrome business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | ACS chemical neuroscience. 11(2) |
| ISSN: | 1948-7193 |
| Popis: | Dementia frequently occurs in Down syndrome (DS) patients, and early intervention is important in its management. We have previously demonstrated a positive correlation of plasma β-amyloid Aβ42 levels and negative correlations of Aβ40 and tau levels with dementia in DS. In this study, we examined more cases and constructed composite scores with both tau and amyloids to correlate with dementia in DS. Plasma Aβ42, Aβ40, and tau proteins were measured by an immunomagnetic reduction assay in DS patients. Data were randomly and repeatedly split into training and validating sets, and logistic regression was applied to calculate the area under the curve (AUC) for each biomarker. A total of 73 DS patients (among them, 23 had neurodegeneration) and 77 controls were recruited. In DS patients without dementia, plasma Aβ40 and tau levels were highly elevated, but Aβ42 levels were lower than those of the healthy controls. DS patients with dementia, compared with DS patients with no dementia, had a large decline in Aβ40 and tau but a rise in Aβ42. For biomarker scores correlating with dementia, Aβ40 revealed an AUC of 0.912; the composite score of Aβ40 × tau revealed an AUC of 0.953; and a combined composite score of 0.1 for Aβ40 × Tau +0.9 Tau × Aβ40/Aβ42 achieved the highest AUC of 0.965. Therefore, composite biomarker scores including both plasma tau and β-amyloid levels correlate with dementia in DS better than using individual biomarker scores. The pattern of tau decline and Aβ42 rise in DS patients with dementia are also different from previous findings in Alzheimer's disease. |
| Databáze: | OpenAIRE |
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