Polyclonal Bence Jones Proteinuria Associated with Reactive Plasmacytosis
| Autor: | Pamela Rowe, Samuel Ariad, Stanley W. Tarlton, Dorothy Lewis, Barry V. Mendelow |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Cancer Research
biology business.industry Plasmacytosis Hepatosplenomegaly Hematology Gene rearrangement medicine.disease_cause Immunoglobulin light chain medicine.disease Epstein–Barr virus Bence Jones protein Oncology Monoclonal Immunology medicine biology.protein medicine.symptom Antibody business |
| Zdroj: | Leukemialymphoma. 3(2) |
| ISSN: | 1042-8194 |
| Popis: | A 43 year old black male patient presented with progressive respiratory symptoms, fever and malaise of short duration accompanied by mild epistaxis. Physical examination revealed generalised lymphadenopathy and hepatosplenomegaly. Peripheral blood examination showed a striking plasmacytosis. Further investigation revealed Bence Jones proteinuria consisting of both kappa and lambda light chains. There was no monoclonal peak on serum electrophoresis and cytoplasmic immunoglobulin and gene rearrangement studies on the peripheral blood plasma cells demonstrated polyclonality. The possible role of Epstein-Barr virus in stimulating B cell proliferation in this case is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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