Hospitalization and Mortality Risk for COVID-19 Cases With SARS-CoV-2 AY.4.2 (VUI-21OCT-01) Compared to Non-AY.4.2 Delta Variant Sublineages
| Autor: | Nyberg, Tommy, Harman, Katie, Zaidi, Asad, Seaman, Shaun R, Andrews, Nick, Nash, Sophie G, Charlett, Andre, Lopez Bernal, Jamie, Myers, Richard, Groves, Natalie, Gallagher, Eileen, Gharbia, Saheer, Chand, Meera, Thelwall, Simon, De Angelis, Daniela, Dabrera, Gavin, Presanis, Anne M |
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| Přispěvatelé: | Nyberg, Tommy [0000-0002-9436-0626], Harman, Katie [0000-0003-1387-0200], Zaidi, Asad [0000-0002-6420-2539], Seaman, Shaun R [0000-0003-3726-5937], Andrews, Nick [0000-0003-2069-2684], Nash, Sophie G [0000-0002-7717-6982], Charlett, Andre [0000-0001-7154-0432], Lopez Bernal, Jamie [0000-0002-1301-5653], Myers, Richard [0000-0003-4269-1164], Groves, Natalie [0000-0002-3832-3484], Gharbia, Saheer [0000-0003-0206-051X], Chand, Meera [0000-0001-9697-0340], Thelwall, Simon [0000-0002-0434-2724], De Angelis, Daniela [0000-0001-6619-6112], Dabrera, Gavin [0000-0003-4606-5945], Presanis, Anne M [0000-0003-3078-4427], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | The Journal of infectious diseases. 226(5) |
| ISSN: | 1537-6613 |
| Popis: | Funder: NIHR Health Protection Unit in Behavioural Science and Evaluation To investigate if the AY.4.2 sublineage of the SARS-CoV-2 delta variant is associated with hospitalization and mortality risks that differ from non-AY.4.2 delta risks, we performed a retrospective cohort study of sequencing-confirmed COVID-19 cases in England based on linkage of routine health care datasets. Using stratified Cox regression, we estimated adjusted hazard ratios (aHR) of hospital admission (aHR = 0.85; 95% confidence interval [CI], .77-.94), hospital admission or emergency care attendance (aHR = 0.87; 95% CI, .81-.94), and COVID-19 mortality (aHR = 0.85; 95% CI, .71-1.03). The results indicate that the risks of hospitalization and mortality are similar or lower for AY.4.2 compared to cases with other delta sublineages. |
| Databáze: | OpenAIRE |
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