Acid Acclimation byHelicobacter pylori
| Autor: | Klaus Melchers, Yi Wen, David L. Weeks, George Sachs, Elizabeth A. Marcus, David R. Scott |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Urease
Physiology Peptic Acclimatization Microbiology Gastric Acid chemistry.chemical_compound Carbonic anhydrase medicine Animals Humans Helicobacter pylori biology Stomach digestive oral and skin physiology Periplasmic space biology.organism_classification Adaptation Physiological digestive system diseases medicine.anatomical_structure chemistry Biochemistry biology.protein Urea |
| Zdroj: | Physiology. 20:429-438 |
| ISSN: | 1548-9221 1548-9213 |
| DOI: | 10.1152/physiol.00032.2005 |
| Popis: | Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, UreI, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to ~6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach. |
| Databáze: | OpenAIRE |
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